Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

• Main Authors: Fen Liu (Author), Bofeng Zhu (Author), Ying An (Author), Zhifei Zhou (Author), Peiying Xiong (Author), Xuan Li (Author), Yang Mi (Author), Tongqiang He (Author), Faming Chen (Author), Buling Wu (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may participate in insulin resistance (IR) caused by periodontal inflammation, but the functional role and specific mechanisms of P. gingivalis in IR remain unclear. In the prese...