Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters

• Main Authors: Katrin Schaar (Author), Anja Geisler (Author), Milena Kraus (Author), Sandra Pinkert (Author), Markian Pryshliak (Author), Jacqueline F. Spencer (Author), Ann E. Tollefson (Author), Baoling Ying (Author), Jens Kurreck (Author), William S. Wold (Author), Robert Klopfleisch (Author), Karoly Toth (Author), Henry Fechner (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that induce RNAi represent a new class of promising ant...