Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.

• Main Authors: Siddharth Jayaraman (Author), Claire Harris (Author), Edith Paxton (Author), Anne-Marie Donachie (Author), Heli Vaikkinen (Author), Richard McCulloch (Author), James P J Hall (Author), John Kenny (Author), Luca Lenzi (Author), Christiane Hertz-Fowler (Author), Christina Cobbold (Author), Richard Reeve (Author), Tom Michoel (Author), Liam J Morrison (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a large repertoire of ~2,000 genes. T. brucei express...