Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1

• Main Authors: Hongkang Wang (Author), Zhe Ji (Author), Yanru Feng (Author), Tianhua Yan (Author), Yongbing Cao (Author), Hui Lu (Author), Yuanying Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Extrusion of azoles from the cell, mediated by an efflux pump Cdr1, is one of the most frequently used strategies for developing azole resistance in pathogenic fungi. The efflux pump Cdr1 is predominantly localized in lipid rafts within the plasma membrane, and its localization is sens...