In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein

• Main Authors: Debora Baroni (Author), Naomi Scarano (Author), Alessandra Ludovico (Author), Chiara Brandas (Author), Alice Parodi (Author), Dario Lunaccio (Author), Paola Fossa (Author), Oscar Moran (Author), Elena Cichero (Author), Enrico Millo (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in the Caucasian population, is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secret...