Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant

• Ngā kaituhi matua: Ishani Landry (Author), Jagadeesh Aluri (Author), Nancy Hall (Author), Gleb Filippov (Author), Satish Dayal (Author), Margaret Moline (Author), Larisa Reyderman (Author)
• Hōputu: Pukapuka
• I whakaputaina: Wiley, 2021-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract The primary aim of this study was to examine the effect of severe renal impairment (SRI) on the pharmacokinetics of lemborexant, a dual orexin receptor antagonist indicated for the treatment of insomnia. A phase 1 multicenter, single‐dose, open‐label, parallel‐group study was conducted in s...