Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

• मुख्य लेखकों: Shih-Yin Ho (लेखक), Li Lin (लेखक), I-Chun Chen (लेखक), Che-Wen Tsai (लेखक), Fang-Chia Chang (लेखक), Horng-Huei Liou (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1aE1099X/+). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurrent...