Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

• Main Authors: Shih-Yin Ho (Author), Li Lin (Author), I-Chun Chen (Author), Che-Wen Tsai (Author), Fang-Chia Chang (Author), Horng-Huei Liou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1aE1099X/+). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurrent...