Loss- and Gain-of-Function Approaches Indicate a Dual Role Exerted by Regulatory T Cells in Pulmonary Paracoccidioidomycosis.

• Main Authors: Silvia B Bazan (Author), Tania A Costa (Author), Eliseu Frank de Araújo (Author), Claudia Feriotti (Author), Flávio V Loures (Author), Fernando D Pretel (Author), Vera L G Calich (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paracoccidioidomycosis (PCM), is a pulmonary fungal disease whose severity depends on the adequate development of T cell immunity. Although regulatory T (Treg) cells were shown to control immunity against PCM, deleterious or protective effects were described in different experimental settings. To cl...