Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

• Main Authors: Daniel P. Zimmer (Author), Courtney M. Shea (Author), Jenny V. Tobin (Author), Boris Tchernychev (Author), Peter Germano (Author), Kristie Sykes (Author), Ali R. Banijamali (Author), Sarah Jacobson (Author), Sylvie G. Bernier (Author), Renee Sarno (Author), Andrew Carvalho (Author), Yueh-tyng Chien (Author), Regina Graul (Author), Emmanuel S. Buys (Author), Juli E. Jones (Author), James D. Wakefield (Author), Gavrielle M. Price (Author), Jennifer G. Chickering (Author), G. Todd Milne (Author), Mark G. Currie (Author), Jaime L. Masferrer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologic mediator NO. sGC stimulators are small...