Novel Biphasic Role of Resolvin D1 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts Is Partly through PI3K/AKT and ERK2 Pathways

• Main Authors: Derong Wu (Author), Shengxing Zheng (Author), Wenjuan Li (Author), Li Yang (Author), Yongjian Liu (Author), Xia Zheng (Author), Yi Yang (Author), Liangmin Yang (Author), Qian Wang (Author), Fang Gao Smith (Author), Shengwei Jin (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblasts, far frombeing merely bystander cells, are known to play a specific role in inflammation resolution after an acute injury. As the endogenous "braking signal," resolvins possess potent anti-inflammatory and proresolution actions. We demonstrated that the expression of COX-2 prot...