Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation
Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibo...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Elsevier,
2018-10-01T00:00:00Z.
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