Inhibition of Arachidonic Acid Release by Cytosolic Phospholipase A2 Is Involved in the Antiapoptotic Effect of FK506 and Cyclosporin A on Astrocytes Exposed to Simulated Ischemia In Vitro

In the present study, we investigated whether the protective effect of FK506 and cyclosporin A (CsA) against in vitro ischemic injury of astrocytes might be mediated through attenuation of cytosolic isoform of phospholipase A2 (cPLA2) expression and activity as well as inhibition of arachidonic acid...

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Main Authors: Bozena Gabryel (Author), Malgorzata Chalimoniuk (Author), Anna Stolecka (Author), Katarzyna Waniek (Author), Jozef Langfort (Author), Andrzej Malecki (Author)
Format: Book
Published: Elsevier, 2006-01-01T00:00:00Z.
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Call Number: A1234.567
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