Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

• Principais autores: Hoda Soleymani Abyaneh (Autor), Amir Hassan Soleimani (Autor), Mohammad Reza Vakili (Autor), Rania Soudy (Autor), Kamaljit Kaur (Autor), Francesco Cuda (Autor), Ali Tavassoli (Autor), Afsaneh Lavasanifar (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2018-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two stra...