Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

• Main Authors: Hoda Soleymani Abyaneh (Author), Amir Hassan Soleimani (Author), Mohammad Reza Vakili (Author), Rania Soudy (Author), Kamaljit Kaur (Author), Francesco Cuda (Author), Ali Tavassoli (Author), Afsaneh Lavasanifar (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two stra...