A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy

• Main Authors: Wenzhao Zhong (Author), Feng Guo (Author), Fangman Chen (Author), Man-Kay Law (Author), Jun Lu (Author), Dan Shao (Author), Hua Yu (Author), Ging Chan (Author), Meiwan Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemodynamic therapy (CDT) eradicates tumors by intratumoral catalytic chemical reaction and subsequently disrupts redox homeostasis, which shows tumor specific reactive oxygen species (ROS)-mediated therapy. However, insufficient ROS generation and high levels of glutathione (GSH) in cancer cells h...