Pharmacophore Based Virtual Screening and Docking of Different Aryl Sulfonamide Derivatives of 5HT7R Antagonist

• Main Authors: Nahid Fatema (Author), Vijjulatha Manga (Author), Lingala Yamini (Author), Salman Ahmad Khan (Author), Qasim Ullah (Author)
• Formato: Livro
• Publicado em: Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya, 2022-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The selective blockade of 5HT7R (5-hydroxytryptamine 7 receptor) displays an antidepressant-like activity. It is a Gs-coupled receptor, which inactivates the adenyl cyclase enzyme or activates the potassium ion channel. Structural information of 5HT7 was obtained by homology modeling using MODELLER...