Facile synthesis of insulin fusion derivatives through sortase A ligation

• Main Authors: Maria M. Disotuar (Author), Jake A. Smith (Author), Jinze Li (Author), Steve Alam (Author), Nai-Pin Lin (Author), Danny Hung-Chieh Chou (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to retain insulin bioactivity. New and efficient metho...