Subthreshold Cannabidiol Potentiates Levetiracetam in the Kainic Acid Model of Temporal Lobe Epilepsy: A Pilot Study

• Main Authors: Chiara Lucchi (Author), Mattia Marcucci (Author), Kawther Ameen Muhammed Saeed Aledresi (Author), Anna-Maria Costa (Author), Giuseppe Cannazza (Author), Giuseppe Biagini (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Refractoriness to antiseizure medications is still a major concern in the pharmacotherapy of epilepsy. For this reason, we decided to evaluate the combination of levetiracetam and cannabidiol, administered at a subthreshold dose, to limit the possible adverse effects of this phytocannabinoid. We adm...