Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H₂O₂-Induced Cellular Toxicity

• Main Authors: Sara Franceschelli (Author), Paola Lanuti (Author), Alessio Ferrone (Author), Daniela Maria Pia Gatta (Author), Lorenza Speranza (Author), Mirko Pesce (Author), Alfredo Grilli (Author), Ivana Cacciatore (Author), Emanuela Ricciotti (Author), Antonio Di Stefano (Author), Sebastiano Miscia (Author), Mario Felaco (Author), Antonia Patruno (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overco...