Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways
Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhances reactive oxygen species (ROS) production and apoptosis of h...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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