50 Therapeutic opportunities in the master transcription factor circuitries of clear cell carcinomas

• Main Authors: Nolan J. Kinne (Author), Soledad Ochoa (Author), Marla Scott (Author), Forough Abbasi (Author), Pak Hin Yu (Author), Marcela Haro (Author), BJ Rimel (Author), Kate Lawrenson (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Transcription factors are emerging as targets for novel therapeutics for the treatment of malignancies. We sought to evaluate functions of PAX8 and HNF1B in both clear cell ovarian cancer (CCOC) and clear cell renal cell carcinoma (ccRCC) to ask whether these factors control tissue-speci...