A sensitive method for analyzing fluconazole in extremely small volumes of neonatal serum

• Main Authors: Jumpei Saito (Author), Ayano Tanzawa (Author), Yuka Kojo (Author), Hidehiko Maruyama (Author), Tetsuya Isayama (Author), Kensuke Shoji (Author), Yushi Ito (Author), Akimasa Yamatani (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The need for a large volume of serum sample significantly reduces the feasibility of neonatal pharmacokinetic studies in daily practice, which must often rely on scavenged or opportunistic sampling. This problem is most apparent in preterm newborns, where ethical and practical co...