Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route

Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route

Background and Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection. Experimental approach: Dilution of the emulsion with methyl-b-cyclodextrin i...

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Main Authors: Michele Domenico Spampinato (Author), Anna Costanzini (Author), Roberto De Giorgio (Author), Angelina Passaro (Author), Nicola Realdon (Author), Fabrizio Bortolotti (Author), Sabrina Banella (Author), Gaia Colombo (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2024-08-01T00:00:00Z.
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3rd Floor Main Library

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