Mutant BCL11B in a Patient With a Neurodevelopmental Disorder and T-Cell Abnormalities

• Main Authors: Sai Yang (Author), Qingyun Kang (Author), Yanqi Hou (Author), Lili Wang (Author), Liping Li (Author), Shulei Liu (Author), Hongmei Liao (Author), Zhenhua Cao (Author), Liming Yang (Author), Zhenghui Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background:BCL11B encodes B-cell lymphoma/leukemia 11B, a transcription factor that participates in the differentiation and migration of neurons and lymphocyte cells. De novo mutations of BCL11B have been associated with neurodevelopmental disorder and immunodeficiency, such as immunodeficiency 49 (...