Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

• Main Authors: Pingping Xue (Author), Wenbo Zhou (Author), Wenqiang Fan (Author), Jianya Jiang (Author), Chengcai Kong (Author), Wei Zhou (Author), Jianmei Zhou (Author), Xiaoyang Huang (Author), Haiyan Yang (Author), Qian Han (Author), Bin Zhang (Author), Lingyun Xu (Author), Bin Yu (Author), Li Chen (Author)
• Format: Book
• Published: BMC, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated to be involved in various biological processes, its potential role in...