Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant

• Main Authors: Gabriela Alves de Souza (Author), Soraia John da Silva (Author), Catarina de Nigris Del Cistia (Author), Paulo Pitasse-Santos (Author), Lucas de Oliveira Pires (Author), Yulli Moraes Passos (Author), Yraima Cordeiro (Author), Cristiane Martins Cardoso (Author), Rosane Nora Castro (Author), Carlos Mauricio R. Sant'Anna (Author), Arthur Eugen Kümmerle (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 3-substituted-7-aminoalcoxy-coumarin was designed and evaluated as cholinesterase inhibitors and antioxidants. All compounds were effective in inhibiting AChE with potencies in the nanomolar range. The 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin (6a) was considered a hit, showing...