Virtual screening and activity evaluation of multitargeting inhibitors for idiopathic pulmonary fibrosis

• Main Authors: Rui Wang (Author), Jian Xu (Author), Rong Yan (Author), Huanbin Liu (Author), Jingxin Zhao (Author), Yuan Xie (Author), Wenbin Deng (Author), Weiping Liao (Author), Yichu Nie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor β receptor (TGF-β1R) and receptor tyrosine kinases (RTKs), such as VEGFRs, PDGFRs and FGFRs are considered important therapeutic targets in blocking myofibroblast migration and activation of idiopathic pulmonary fibrosis (IPF). To screen and design innovative prodrug to si...