Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium

• Main Authors: Manas R. Biswal (Author), Zhaoyao Wang (Author), Ryan J. Paulson (Author), Rukshana R. Uddin (Author), Yao Tong (Author), Ping Zhu (Author), Hong Li (Author), Alfred S. Lewin (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Erythropoietin (EPO) plays an important role in erythropoiesis by its action in blocking apoptosis of progenitor cells and protects both photoreceptors and retinal ganglion cells from induced or inherited degeneration. A modified form of EPO, EPO-R76E has attenuated erythropoietic activity but is ef...