The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

• Main Authors: Heesung Shim (Author), Brandon M. Brown (Author), Latika Singh (Author), Vikrant Singh (Author), James C. Fettinger (Author), Vladimir Yarov-Yarovoy (Author), Heike Wulff (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding...