Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR‐mutant non‐small cell lung cancer

• Main Authors: Julie M. Janssen (Author), Remy B. Verheijen (Author), Tirsa T. vanDuijl (Author), Lishi Lin (Author), Michel M. van denHeuvel (Author), Jos H. Beijnen (Author), Neeltje Steeghs (Author), Daan van denBroek (Author), Alwin D. R. Huitema (Author), Thomas P. C. Dorlo (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Correlations between increasing concentrations of circulating tumor DNA (ctDNA) in plasma and disease progression have been shown. A nonlinear mixed effects model to describe the dynamics of epidermal growth factor receptor (EGFR) ctDNA data from patients with non‐small cell lung cancer (NS...