Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)

• Main Authors: Huan Xu (Author), Zhixiao Liu (Author), Dajun Gao (Author), Peizhang Li (Author), Yanting Shen (Author), Yi Sun (Author), Lingfan Xu (Author), Nan Song (Author), Yue Wang (Author), Ming Zhan (Author), Xu Gao (Author), Zhong Wang (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted therapies in cancers has led to the development of highly aggressive carcinoma, including neuroendocrine prostate cancer (NEPC). Although metabolic repr...