Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

• Main Authors: Laura Tamberg (Author), Mariliis Jaago (Author), Kristi Säälik (Author), Alex Sirp (Author), Jürgen Tuvikene (Author), Anastassia Shubina (Author), Carl Sander Kiir (Author), Kaja Nurm (Author), Mari Sepp (Author), Tõnis Timmusk (Author), Mari Palgi (Author)
• Format: Book
• Published: The Company of Biologists, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities, such as Pitt-Hopkins syndrome (PTHS). Here, we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed widely in the Drosophila brain. Furthermore, silencing of...