Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing

• Main Authors: Paul W. Harms (Author), Alexandra C. Hristov (Author), David S. Kim (Author), Tobenna Anens (Author), Michael J. Quist (Author), Javed Siddiqui (Author), Shannon Carskadon (Author), Rohit Mehra (Author), Douglas R. Fullen (Author), Timothy M. Johnson (Author), Arul M. Chinnaiyan (Author), Nallasivam Palanisamy (Author)
• Format: Book
• Published: Elsevier, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that promotes tumorigenesis by epigenetic repression of tumor suppressor genes. Although EZH2 is overexpressed in many malignancies, activating EZH2 mutations have been described predominantly in follicular lymphoma and diffuse large...