TGF-β1-triggered BMI1 and SMAD2 cooperatively regulate miR-191 to modulate bone formation

• Main Authors: Xiao-Fei Zhang (Author), Zi-Xuan Wang (Author), Bo-Wen Zhang (Author), Kun-Peng Huang (Author), Tian-Xing Ren (Author), Ting Wang (Author), Xing Cheng (Author), Ping Hu (Author), Wei-Hua Xu (Author), Jin Li (Author), Jin-Xiang Zhang (Author), Hui Wang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor β 1 (TGF-β1), as the most abundant signaling molecule in bone matrix, is essential for bone homeostasis. However, the signaling transduction of TGF-β1 in the bone-forming microenvironment remains unknown. Here, we showed that microRNA-191 (miR-191) was downregulated during...