NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis

• المؤلفون الرئيسيون: Pengcheng Xing (مؤلف), Minjie Zhou (مؤلف), Jian Sun (مؤلف), Donglian Wang (مؤلف), Weipeng Huang (مؤلف), Peng An (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2024-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Sepsis-induced pulmonary injury (SPI) is a common complication of sepsis with a high rate of mortality. N4-acetylcytidine (ac4C) is mediated by the ac4C "writer", N-acetyltransferase (NAT)10, to regulate the stabilization of mRNA. This study aimed to investigate the rol...