Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

• Main Authors: Xiaopeng Peng (Author), Zhihao Hu (Author), Limei Zeng (Author), Meizhu Zhang (Author), Congcong Xu (Author), Benyan Lu (Author), Chengpeng Tao (Author), Weiming Chen (Author), Wen Hou (Author), Kui Cheng (Author), Huichang Bi (Author), Wanyi Pan (Author), Jianjun Chen (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators (e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges, inc...