A Practical Approach to Immunotherapy of Hepatocellular Carcinoma Using T Cells Redirected Against Hepatitis B Virus

• Main Authors: Sarene Koh (Author), Noriko Shimasaki (Author), Rossarin Suwanarusk (Author), Zi Zong Ho (Author), Adeline Chia (Author), Nasirah Banu (Author), Shanshan Wu Howland (Author), Alice Soh Meoy Ong (Author), Adam J Gehring (Author), Hans Stauss (Author), Laurent Renia (Author), Matti Sällberg (Author), Dario Campana (Author), Antonio Bertoletti (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) cells often have hepatitis B virus (HBV)-DNA integration and can be targeted by HBV-specific T cells. The use of viral vectors to introduce exogenous HBV-specific T-cell receptors (TCR) on T cells to redirect their specificity is complex and expensive to implement in c...