Novel genetic polymorphisms identified in the clinical isolates of Mycobacterium tuberculosis PE_PGRS33 gene modulate cytokines expression and promotes survival in macrophages

• Main Authors: Rahul Gupta (Author), Manitosh Pandey (Author), Amit Kumar Pandey (Author), Pramod Kumar Tiwari (Author), Rabbind Singh Amrathlal (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: PE_PGRS33 is a member of multi-gene family restricted to pathogenic Mycobacteria and their functions remain elusive. PE_PGRS33 is highly polymorphic in nature to evade host's immune response. Therefore, we investigated PE_PGRS33 gene polymorphisms in clinical isolates and functional...