Novel genetic polymorphisms identified in the clinical isolates of Mycobacterium tuberculosis PE_PGRS33 gene modulate cytokines expression and promotes survival in macrophages

• Hlavní autoři: Rahul Gupta (Autor), Manitosh Pandey (Autor), Amit Kumar Pandey (Autor), Pramod Kumar Tiwari (Autor), Rabbind Singh Amrathlal (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2022-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Objective: PE_PGRS33 is a member of multi-gene family restricted to pathogenic Mycobacteria and their functions remain elusive. PE_PGRS33 is highly polymorphic in nature to evade host's immune response. Therefore, we investigated PE_PGRS33 gene polymorphisms in clinical isolates and functional...