Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice.

• Main Authors: Brandon Sit (Author), Ting Zhang (Author), Bolutife Fakoya (Author), Aklima Akter (Author), Rajib Biswas (Author), Edward T Ryan (Author), Matthew K Waldor (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral cholera vaccines (OCVs) are being increasingly employed, but current killed formulations generally require multiple doses and lack efficacy in young children. We recently developed a new live-attenuated OCV candidate (HaitiV) derived from a Vibrio cholerae strain isolated during the 2010 Haiti...