Exploiting orthology and de novo transcriptome assembly to refine target sequence information

• Main Authors: Julia F. Söllner (Author), Germán Leparc (Author), Matthias Zwick (Author), Tanja Schönberger (Author), Tobias Hildebrandt (Author), Kay Nieselt (Author), Eric Simon (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The ability to generate recombinant drug target proteins is important for drug discovery research as it facilitates the investigation of drug-target-interactions in vitro. To accomplish this, the target's exact protein sequence is required. Public databases, such as Ensembl,...