CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• المؤلفون الرئيسيون: Fatemeh Movahedi Motlagh (مؤلف), Hamid Reza Soleimanpour‐Lichaei (مؤلف), Mehdi Shamsara (مؤلف), Azadeh Etemadzadeh (مؤلف), Mohammad Hossein Modarressi (مؤلف)
• التنسيق: كتاب
• منشور في: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...