CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• প্রধান লেখক: Fatemeh Movahedi Motlagh (লেখক), Hamid Reza Soleimanpour‐Lichaei (লেখক), Mehdi Shamsara (লেখক), Azadeh Etemadzadeh (লেখক), Mohammad Hossein Modarressi (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...