CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Hlavní autoři: Fatemeh Movahedi Motlagh (Autor), Hamid Reza Soleimanpour‐Lichaei (Autor), Mehdi Shamsara (Autor), Azadeh Etemadzadeh (Autor), Mohammad Hossein Modarressi (Autor)
• Médium: Kniha
• Vydáno: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...