CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Päätekijät: Fatemeh Movahedi Motlagh (Tekijä), Hamid Reza Soleimanpour‐Lichaei (Tekijä), Mehdi Shamsara (Tekijä), Azadeh Etemadzadeh (Tekijä), Mohammad Hossein Modarressi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...