CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Auteurs principaux: Fatemeh Movahedi Motlagh (Auteur), Hamid Reza Soleimanpour‐Lichaei (Auteur), Mehdi Shamsara (Auteur), Azadeh Etemadzadeh (Auteur), Mohammad Hossein Modarressi (Auteur)
• Format: Livre
• Publié: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...