CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• मुख्य लेखकों: Fatemeh Movahedi Motlagh (लेखक), Hamid Reza Soleimanpour‐Lichaei (लेखक), Mehdi Shamsara (लेखक), Azadeh Etemadzadeh (लेखक), Mohammad Hossein Modarressi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...