CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Váldodahkkit: Fatemeh Movahedi Motlagh (Dahkki), Hamid Reza Soleimanpour‐Lichaei (Dahkki), Mehdi Shamsara (Dahkki), Azadeh Etemadzadeh (Dahkki), Mohammad Hossein Modarressi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...