Safety and tolerability of topical trametinib in rosacea: Results from a phase I clinical trial

• Main Authors: Edward J. Wladis (Author), Jacqueline Busingye (Author), Leahruth K. Saavedra (Author), Amy Murdico (Author), Alejandro P. Adam (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose Overactivation of the mitogen activated kinase pathway has been associated with rosacea. We hypothesised that inhibitors of this pathway can be repurposed to alleviate rosacea symptoms. Methods In order to test this hypothesis, we designed a double‐blind, randomised, placebo‐control...