Myeloperoxidase-Oxidized LDLs Enhance an Anti-Inflammatory M2 and Antioxidant Phenotype in Murine Macrophages

• Main Authors: Valérie Pireaux (Author), Aude Sauvage (Author), Benoît Bihin (Author), Martine Van Steenbrugge (Author), Alexandre Rousseau (Author), Pierre Van Antwerpen (Author), Karim Zouaoui Boudjeltia (Author), Martine Raes (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages and oxidized LDLs play a key role in atherogenesis but their heterogeneity has been neglected up to now. Macrophages are prone to polarization and subsets of polarized macrophages have been described in atheromas. LDLs can be oxidized not only chemically by copper (Ox-LDLs) but also enzy...