Berberine Attenuates Cell Motility via Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis

• Main Authors: Yishan Du (Author), Muhammad Khan (Author), Nana Fang (Author), Fang Ma (Author), Hongzhi Du (Author), Zhenya Tan (Author), Hua Wang (Author), Shi Yin (Author), Xiaohui Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lysyl hydroxylase-2 (LH2) involves in the hydroxylation of telopeptide lysine residues during collagen deposition. Recent studies indicate that interleukin (IL)-6 generated by the chronic inflammation disease may trigger the LH2 expression to accelerate cell motility. Berberine is the alkaloid deriv...